(a) Slimicides may be safely used in the manufacture of paper and paperboard that contact food, in accordance with the following prescribed conditions:
(1) Slimicides are used as antimicrobial agents to control slime in the manufacture of paper and paperboard.
(2) Subject to any prescribed limitations, slimicides are prepared from one or more of the slime-control substances named in paragraph (c) of this section to which may be added optional adjuvant substances as provided for under paragraph (d) of this section.
(3) Slimicides are added to the process water used in the production of paper or paperboard, and the quantity added shall not exceed the amount necessary to accomplish the intended technical effect.
(b) To insure safe usage, the label or labeling of slimicides shall bear adequate directions for use.
(c) Slime-control substances permitted for use in the preparation of slimicides include substances subject to prior sanction or approval for such use and the following: ------------------------------------------------------------------------
List of substances Limitations------------------------------------------------------------------------Acrolein...............................Alkenyl (C16-C18) dimethylethyl-
ammonium bromide.n-Alkyl (C12-C18) dimethyl benzyl
ammonium chloride.1,2-Benzisothiazolin-3-one............. At a level of 0.06 pound per
ton of dry weight fiber.Bis(1,4-bromoacetoxy)-2-butene.........5,5-Bis(bromoacetoxymethyl) m-dioxane..2,6-Bis(dimethylaminomethyl)
cyclohexanone.1,2-Bis(monobromoacetoxy) ethane [CA At a maximum level of 0.10
Reg. No. 3785-34-0]. pound per ton of dry weight
fiber.Bis(trichloromethyl)sulfone............4-Bromoacetoxymethyl-m-dioxolane.......2-Bromo-4'-hydroxyacetophenone.........2-Bromo-2-nitropropane-1,3-diol (CAS At a maximum level of 0.6 pound
Reg. No. 52-51-7). per ton of dry weight fiber.[beta]-Bromo-[beta]-nitrostyrene....... At a maximum level of 1 pound
per ton of dry weight fiber.Chloroethylenebisthiocyanate...........5-Chloro-2 - methyl - 4 - isothiazolin- At a level of 2.5 pounds per
3-one calcium chloride and 2-methyl-4- ton of dry weight fiber.
isothiazolin-3-one calcium chloride
mixture at a ratio of 3 parts to 1
part.Chlorinated levulinic acids............Chloromethyl butanethiolsulfonate......Cupric nitrate.........................
n-Dialkyl (C12-C18)
benzylmethylammonium chloride.1,2-Dibromo-2,4-dicyanobutane (CAS Reg. At a maximum level of 0.005% of
No. 35691-65-7). dry weight fiber.2,2-Dibromo-3-nitrilopropionamide...... At a maximum level of 0.1 lb/
ton of dry weight fiber.2,3-Dibromopropionaldehyde.............4,5-dichloro-1, 2-dithiol-3-one (CAS For use only at levels not to
Reg. No. 1192-52-5). exceed 10 milligrams per
kilogram in the pulp slurry.1,3-Dihalo-5,5-dimethylhydantoin (where At a maximum level of 1.0
the dihalo (halogen) may be bromine kilogram (kg) per 1,000 kg of
and/or chlorine) that may contain no dry weight fiber.
more than 20 weight percent 1,3-dihalo-
5-ethyl-5-methylhydantoin (where the
dihalo (halogen) may be bromine and/or
chlorine)..4-(Diiodomethylsulfonyl) toluene (CAS At a maximum level of 0.2 pound
Reg. No. 20018-09-1).. per ton (100 grams/1,000
kilograms) of dry weight
fiber.3,5-Dimethyl 1,3,5,2H-
tetrahydrothiadiazine-2-thione.Dipotassium and disodium
ethylenebis(dithiocarba-mate).Disodium cyanodithioimidocarbonate.....n-Dodecylguanidine hydrochloride....... At a maximum level of 0.20
pound per ton of dry weight
fiber.Glutaraldehyde (CAS Reg. No. 111-30-8).2-(p-hydroxyphenyl) glyoxylohydroximoyl At a level of 0.02 pound per
chloride (CAS Registry No. 34911-46-1). ton of dry weight fiber.2-Hydroxypropyl methanethiol sulfonate.2-Mercaptobenzothiazole................Methylenebisbutanethiolsulfonate.......Methylenebisthiocyanate................2-Nitrobutyl bromoacetate [CA Reg. No. At a maximum level of 0.15
32815-96-6]. pound per ton of dry weight
fiber.N-[[alpha]-(Nitroethyl)benzyl]
ethylenediamine.Potassium 2-mercaptobenzothiazole......Potassium N-hydroxymethyl-N-
methyldithiocarba-mate.Potassium N-methyldithiocarbamate......Potassium pentachlorophenate...........Potassium trichlorophenate.............Silver fluoride........................ Limit of addition to process
water not to exceed 0.024
pound, calculated as silver
fluoride, per ton of paper
produced.Silver nitrate.........................Sodium dimethyldithiocarbamate.........Sodium 2-mercaptobenzothiazole.........Sodium pentachlorophenate..............Sodium trichlorophenate................1,3,6,8-Tetraazatricyclo[6.2.1.13,6]
dodecane.3,3,4,4-Tetrachlorotetrahydrothiophene-
1,1-dioxide.Tetrakis(hydroxymethyl)phosphonium Maximum use level of 84 mg/kg
sulfate (CAS Reg. No. 55566-30-8). in the pulp slurry. The
additive may also be added to
water, which when introduced
into the pulp slurry, results
in a concentration in the pulp
slurry not to exceed 84 mg/kg.2-(Thiocyanomethylthio) benzothiazole..Vinylene bisthiocyanate................------------------------------------------------------------------------
(d) Adjuvant substances permitted to be used in the preparation of slimicides include substances generally recognized as safe for use in food, substances generally recognized as safe for use in paper and paperboard, substances permitted to be used in paper and paperboard by other regulations in this chapter, and the following: Acetone.Butlylene oxide.Dibutyl phthalate.Didecyl phthalate.N,N-Dimethylformamide.Dodecyl phthalate.Ethanolamine.Ethylene glycol.Ethylenediamine.N-methyl-2-pyrrolidone (CAS Reg. No. 872-50-4).a,a'-[Methylenebis[4-(1,1,3,3-tetra methyl butyl)-o-phenylene]] bis[omega-hydroxypoly (oxyethylene)] having 6-7.5 moles of ethylene oxide per hydroxyl group.Monomethyl ethers of mono-, di-, and tri propyl ene glycol.Nonylphenol reaction product with 9 to 12 molecules of ethylene oxide.Octylphenol reaction product with 25 molecules of propylene oxide and 40 molecules of ethylene oxide. [42 FR 14554, Mar. 15, 1977, as amended at 42 FR 41854, Aug. 19, 1977; 44 FR 75627, Dec. 21, 1979; 46 FR 36129, July 14, 1981; 49 FR 5748, Feb. 15, 1984; 51 FR 19059, May 27, 1986; 51 FR 43734, Dec. 4, 1986; 54 FR 18103, Apr. 27, 1989; 55 FR 31825, Aug. 6, 1990; 64 FR 46130, Aug. 24, 1999; 64 FR 69900, Dec. 15, 1999; 65 FR 40497, June 30, 2000; 65 FR 70790, Nov. 28, 2000; 69 FR 24512, May 4, 2004]