Code of Federal Regulations (alpha)

CFR /  Title 21  /  Part 558  /  Sec. 558.258 Fenbendazole.

(a) Specifications. Type A medicated articles: 4 percent (18.1 grams per pound (g/lb)), 8 percent (36.2 g/lb), and 20 percent (90.7 g/lb) fenbendazole.

(b) Approvals. See No. 000061 in Sec. 510.600(c) of this chapter.

(c) Related tolerances. See Sec. 556.275 of this chapter.

(d) Special considerations. See Sec. 500.25 of this chapter.

(e) Conditions of use--(1) Turkeys. ----------------------------------------------------------------------------------------------------------------

Amount fenbendazole in grams per Combination in grams

ton per ton Indications for use Limitations Sponsor----------------------------------------------------------------------------------------------------------------14.5 (16 parts per million)...... .................... Growing turkeys: For Feed continuously 000061

the removal and as the sole ration

control of for 6 days. For

gastrointestinal growing turkeys

worms: roundworms, only.

adult and larvae

(Ascaridia

dissimilis); cecal

worms, adult and

larvae (Heterakis

gallinarum), an

important vector of

Histomonas meleagridis

(Blackhead).----------------------------------------------------------------------------------------------------------------

(2) Swine. ----------------------------------------------------------------------------------------------------------------

Amount fenbendazole in grams per Combination in grams

(i) 10 to 300 (to provide 9 .................... For the removal and Feed as sole ration 000061

milligrams per kilogram (mg/kg) control of: Adult

of body weight) given over a 3- stage lungworms

to 12-day period. (Metastrongylus apri

and M. pudendotectus);

adult and larvae (L3,

4 stages--liver, lung,

intestinal forms)

large roundworms

(Ascaris suum); adult

stage nodular worms

(Oesophagostomum

dentatum, O.

quadrispinulatum);

adult stage small

stomach worms

(Hyostrongylus

rubidus); adult and

larvae (L2, 3, 4

stages--intestinal

mucosal forms)

whipworms (Trichuris

suis); adult and

larvae kidney worms

(Stephanurus dentatus).(ii) 10 to 80 (to provide 9 mg/kg Lincomycin 20....... As in paragraph Feed as sole 000061

(i) of this ration. Do not

section; for increased feed to swine that

rate of gain in weigh more than

growing-finishing 250 pounds (lbs);

swine. lincomycin as

provided by 054771

in Sec.

510.600(c) of this

chapter.(iii) 10 to 80 (to provide 9 mg/ Lincomycin 40....... As in paragraph Feed as sole 000061

(i) of this ration. Do not

section; for control feed to swine that

of swine dysentery in weigh more than

animals on premises 250 lbs.;

with a history of lincomycin as

swine dysentery, but provided by 054771

where symptoms have in Sec.

not yet occurred. 510.600(c) of this

chapter.(iv) 10 to 80 (to provide 9 mg/kg Lincomycin 100...... As in paragraph Feed as sole 000061

(i) of this ration. Do not use

section; for the within 6 days of

treatment of swine slaughter. Do not

dysentery. feed to swine that

weigh more than

250 lbs.;

lincomycin as

provided by 054771

in Sec.

510.600(c) of this

chapter.(v) 10 to 80 (to provide 9 mg/kg Lincomycin 200...... As in paragraph Feed as sole 000061

(i) of this ration. Do not use

section; for reduction within 6 days of

in the severity of slaughter. Do not

swine mycoplasmal feed to swine that

pneumonia caused by weigh more than

Mycoplasma 250 pound (lb);

hyopneumoniae. lincomycin as

provided by 054771

in Sec.

510.600(c) of this

chapter.(vi) 10 to 300 (to provide 9 mg/ Bacitracin methylene Growing/finishing Feed as sole 054771

kg of body weight). disalicylate 10 to swine: As in paragraph ration. Under

(i) of this conditions of

section; for increased continued exposure

rate of weight gain to parasites,

and improved feed retreatment may be

efficiency. needed after 4 to

6 weeks.

Bacitracin

methylene

disalicylate as

provided by 054771

in Sec.

510.600(c) of this

chapter.(vii) 10 to 300 (to provide 9 mg/ Bacitracin methylene 1. Growing/finishing 1. Growing/ 054771

kg of body weight). disalicylate 250. swine: As in paragraph finishing swine:

(e)(2)(i) of this Feed as sole

(2)(i) of this Feed as sole

(i) of this Feed as sole

section; for control ration. Not for

of swine dysentery use in growing and

associated with finishing swine

Treponema that weigh more

hyodysenteriae on than 250 lbs.

premises with a Diagnosis of swine

history of swine dysentery should

dysentery, but where be confirmed by a

signs of disease have veterinarian when

not yet occurred; or results are not

following an approved satisfactory.

treatment of the Under conditions

disease condition. of continued

exposure to

parasites,

retreatment may be

needed after 4 to

6 weeks.

Bacitracin

methylene

disalicylate as

provided by 054771

in Sec.

510.600(c) of this

chapter.

.................... 2. Pregnant sows: As in 2. Pregnant sows: .........

paragraph (e)(2)(i) of Feed as sole

this section; for ration. Diagnosis

control of clostridial of clostridial

enteritis in suckling enteritis should

pigs caused by be confirmed by a

Clostridium veterinarian when

perfringens. results are not

satisfactory.

Under conditions

of continued

exposure to

parasites,

retreatment may be

needed after 4 to

6 weeks.

Bacitracin

methylene

disalicylate as

provided by 054771

in Sec.

510.600(c) of this

chapter.----------------------------------------------------------------------------------------------------------------

(3) Cattle. ------------------------------------------------------------------------

Amount Indications for

(i) 5 mg/kg Dairy and beef Feed as the sole 000061

body weight cattle: For ration or as a

(2.27 mg/lb) the removal top dress for one

and control day. Retreatment

of: Lungworms may be needed

(Dictyocaulus after 4 to 6

viviparus); weeks. Cattle

Stomach worms: must not be

barberpole slaughtered

worms within 13 days

(Haemonchus following last

contortus), treatment. For

brown stomach dairy cattle the

worms milk discard time

(Ostertagia is zero hours. A

ostertagi), withdrawal period

small stomach has not been

worms established for

(Trichostrongy this product in

lus axei); pre-ruminating

Intestinal calves. Do not

worms: use in calves to

hookworms be processed for

(Bunostomum veal..

phlebotomum),

thread-necked

intestinal

worms

(Nematodirus

helvetianus),

small

intestinal

worms

(Cooperia

oncophora and

C. punctata);

Bankrupt worms

(Trichostrongy

lus

colubriformis)

; and Nodular

worms

(Oesophagostom

um radiatum).(ii) [Reserved]------------------------------------------------------------------------

(iii) Free-choice feeds--(A) Amount. 5 mg/kg body weight (2.27 mg/lb), including the following formulations: ----------------------------------------------------------------------------------------------------------------

(1) Free-choice, dry Type C feed: .................................. ..................................

Salt (sodium chloride) 59.00 6-04-152

Monosodium phosphate 31.16 6-04-288

Dried cane molasses 3.12 4-04-695

Zinc sulfate 0.76 6-05-556

Copper sulfate 0.45 6-01-720

Fenbendazole 20% Type A article 5.51 n/a(2) Free-choice, dry Type C feed: .................................. ..................................

Salt (sodium chloride) 35.93 6-04-152

Dicalcium phosphate (18.5% P) 32.44 6-00-080

Calcium carbonate (38% Ca) 15.93 6-01-069

Magnesium oxide (56% Mg) 10.14 6-02-756

Zinc sulfate 1.47 6-05-556

Mineral oil 1.00 8-03-123

Dried cane molasses (46% sugars) 0.98 4-04-695

Potassium iodide 0.01 6-03-759

Fenbendazole 20% Type A article 2.10 n/a(3) Free-choice, liquid Type C feed:

Cane molasses\2\ 80.902 4-13-251

Water 9.36 n/a

Urea solution, 55% 7.05 5-05-707

Phosphoric acid 75% (feed grade) 2.00 6-03-707

Xantham gum 0.20 8-15-818

Trace minerals 0.20 n/a

Vitamin premix 0.01 n/a

Fenbendazole 20% Type A article 0.278 n/a----------------------------------------------------------------------------------------------------------------\1\The content of any added vitamin and trace mineral may be varied; however, they should be comparable to those

used by the manufacturer for other free-choice cattle feeds. Formulation modifications require FDA approval

prior to marketing. Selenium is not approved for the free-choice formulations described in paragraph

(e)(3)(iii) of this section. Free-choice cattle feeds containing selenium must comply with published

(3)(iii) of this section. Free-choice cattle feeds containing selenium must comply with published

(iii) of this section. Free-choice cattle feeds containing selenium must comply with published

regulations (see 21 CFR 573.920).\2\The percentage of cane molasses and water in the formulation may be adjusted as needed in order to bring the

brix value of the molasses to the industry standard of 79.5 brix.

(B) Indications for use. As in paragraph (e)(3)(i) of this section.

(C) Limitations. Feed a total of 5 mg of fenbendazole per kg (2.27 mg/lb) of body weight to cattle over a 3- to 6-day period. Retreatment may be needed after 4 to 6 weeks. Cattle must not be slaughtered within 13 days following last treatment. For dairy cattle the milk discard time is zero hours. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

(4) Horses. ----------------------------------------------------------------------------------------------------------------

(i) 4,540............................. 5 mg/kg body weight (2.27 mg/ Feed at the rate of 0. 1lb of 000061

lb) for the control of large feed per 100 lb of body

strongyles (Strongylus weight to provide 2.27 mg

edentatus, S. equinus, S. fenbendazole/lb of body

vulgaris, Triodontophorus weight in a 1-day treatment

spp.), small strongyles or 0.2 lb of feed per 100 lb

(Cyathostomum spp., of body weight to provide

Cylicocyclus spp., 4.54 mg fenbendazole/lb of

Cylicostephanus spp.), and body weight in a 1-day

pinworms (Oxyuris equi); 10 treatment. All horses must

mg/kg body weight (4.54 mg/ be eating normally to ensure

lb) for the control of that each animal consumes an

ascarids (Parascaris adequate amount of the

equorum).. medicated feed. Regular

deworming at intervals of 6

to 8 weeks may be required

due to the possibility of

reinfection. Do not use in

horses intended for human

consumption..(ii) [Reserved]....................... .............................. ............................. .........----------------------------------------------------------------------------------------------------------------

(5) Zoo and wildlife animals. ----------------------------------------------------------------------------------------------------------------

(i) Feral swine (Sus scrofa)..... 3 mg/kg/day for 3 For the removal and Use as complete 000061

days.. control of kidney worm feed. Prior

(Stephanurus withdrawal of feed

dentatus), roundworm or water is not

(Ascaris suum), necessary.

nodular worm Retreatment may be

(Oesophagostomum required in 6

dentatum). weeks. Do not use

14 days before or

during the hunting

season.(ii) Ruminants (subfamily 2.5 mg/kg/day for 3 For the removal and Use as complete 000061

Antilopinae, Hippotraginae, days.. control of small feed. Prior

Caprinae). stomach worm withdrawal of feed

(Trichostrongylus or water is not

spp.), thread necked necessary.

intestinal worm Retreatment may be

(Nematodirus spp.), required in 6

barberpole worm weeks. Do not use

(Haemonchus spp.), 14 days before or

whipworm (Trichuris during the hunting

spp.). season.

(iii) Rocky mountain bighorn 10 mg/kg/day for 3 For the removal and Use as complete 000061

sheep (Ovis c. canadensis). days.. control of feed. Prior

Protostrongylus spp. withdrawal of feed

or water is not

necessary.

Retreatment may be

required in 6

weeks. Do not use

14 days before or

during the hunting

season.---------------------------------------------------------------------------------------------------------------- [66 FR 58935, Nov. 26, 2001, as amended at 68 FR 34534, June 10, 2003; 72 FR 66046, Nov. 27, 2007; 73 FR 58873, Oct. 8, 2008; 74 FR 61517, Nov. 25, 2009; 79 FR 13545, Mar. 11, 2014]