(a) Specifications. (1) Dry Type A medicated articles containing 100 or 200 milligrams (mg) melengestrol acetate per pound.
(1) Dry Type A medicated articles containing 100 or 200 milligrams (mg) melengestrol acetate per pound.
(2) Liquid Type A medicated article containing 500 mg melengestrol acetate per pound.
(b) Approvals. See sponsors in Sec. 510.600(c) of this chapter for use as in paragraph (e) of this section.
(1) No. 054771 for use of products described in paragraph (a) of this section.
(2) No. 000986 for use of product described in paragraph (a)(2) of this section.
(c) Related tolerances. See Sec. 556.380 of this chapter.
(d) Special considerations. (1) Type B or C medicated feeds may be manufactured from melengestrol acetate liquid Type A articles or Type B or C medicated feeds which have a pH of 4.0 to 8.0 and bear appropriate mixing directions as follows:
(1) Type B or C medicated feeds may be manufactured from melengestrol acetate liquid Type A articles or Type B or C medicated feeds which have a pH of 4.0 to 8.0 and bear appropriate mixing directions as follows:
(i) For liquid feeds stored in recirculating tank systems: Recirculate immediately prior to use for no less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used.
(ii) For liquid feeds stored in mechanical, air, or other agitation type tank systems: Agitate immediately prior to use for not less than 10 minutes, creating a turbulence at the bottom of the tank that is visible at the top. Agitate daily as described even when not used.
(2) A physically stable melengestrol acetate liquid Type B or C feed will not be subject to the requirements for mixing directions prescribed in paragraph (d)(1) of this section provided it has a pH of 4.0 to 8.0 and contains a suspending agent(s) sufficient to maintain a viscosity of not less than 300 centipoises per second for 3 months.
(3) Combination Type B or C medicated feeds containing lasalocid must be labeled in accordance with Sec. 558.311(d)(5) of this chapter.
(4) Liquid combination Type B or C medicated feeds containing melengestrol acetate and lasalocid must be manufactured in accordance with Sec. 558.311(d) of this chapter.
(5) Combination Type B or C medicated feeds containing monensin must be labeled in accordance with Sec. 558.355(d) of this chapter.
(6) Liquid combination Type B or C medicated feeds containing melengestrol acetate and monensin must be manufactured in accordance with Sec. 558.355(f)(3)(i) of this chapter.
(7) Liquid combination Type B or C medicated feeds containing melengestrol acetate and tylosin must be manufactured in accordance with Sec. 558.625(c) of this chapter.
(8) Liquid melengestrol acetate may not be mixed with oxytetracycline in a common liquid feed supplement.
(e) Conditions of use--(1) Cattle. ----------------------------------------------------------------------------------------------------------------
Melengestrol acetate in mg/head/ Combination in mg/
(i) 0.25 to 0.5.................. .................... Heifers fed in Administer 0.5 to 054771,
confinement for 2.0 pounds (lb)/ 000986
slaughter: For head/day of
increased rate of medicated feed
weight gain, improved containing 0.125
feed efficiency, and to 1.0 mg
suppression of estrus melengestrol
(heat).. acetate/lb to
provide 0.25 to
0.5 mg
melengestrol
acetate/head/day..(ii) 0.5......................... .................... Heifers intended for Administer 0.5 to 054771,
breeding: For 2.0 lb/head/day of 000986
suppression of estrus Type C feed
(heat).. containing 0.25 to
1.0 mg
melengestrol
acetate/lb to
provide 0.5 mg
melengestrol
acetate/head/day.
Do not exceed 24
days of feeding..(iii) 0.25 to 0.5................ Lasalocid 100 to 360 Heifers fed in Add at the rate of 054771,
confinement for 0.5 to 2.0 lb/head/ 000986
slaughter: As in day a medicated
paragraph (e)(1)(i) of feed (liquid or
this section.. dry) containing
0.125 to 1.0 mg
melengestrol
acetate/lb to a
feed containing 10
to 30 grams (g) of
lasalocid per ton;
or add at the rate
of 0.5 to 2.0 lb/
head/day a
medicated feed
(liquid or dry)
containing 0.125
to 1.0 mg
melengestrol
acetate plus 50 to
720 mg lasalocid/
lb to a ration of
nonmedicated feed
to provide 0.25 to
0.5 mg
melengestrol
acetate and 100 to
360 mg lasalocid/
head/day..
Lasalocid provided
by No. 054771 in
Sec. 510.600(c)
of this chapter..
(iv) 0.25 to 0.5................. Lasalocid 100 to 360 Heifers fed in To administer 0.25 054771,
plus tylosin 90.. confinement for to 0.5 mg 000986,
slaughter: As in melengestrol 016592
paragraph (e)(1)(i) of acetate plus 100
this section; and for to 360 mg
reduced incidence of lasalocid plus 90
liver abscesses caused mg tylosin/head/
by Fusobacterium day:.
necrophorum and 1. Add 0.5 to 2.0
Actinomyces lb/head/day of a
(Corynebacterium) liquid or dry
pyogenes.. medicated feed
containing 0.125
to 1.0 mg
melengestrol
acetate/lb to a
medicated feed
containing 10 to
30 g lasalocid and
8 to 10 g tylosin
per ton; or.
2. Add 0.5 to 2.0
lb/head/day of a
liquid or dry
medicated feed
containing 0.125
to 1.0 mg
melengestrol
acetate plus 50 to
720 mg lasalocid/
lb to 4.5 to 18 lb
of a dry medicated
feed containing 10
to 40 g tylosin
per ton; or.
3. Add 0.5 to 2.0
lb/head/day of a
dry pelleted
medicated feed
containing 0.125
to 1.0 mg
melengestrol
acetate (from a
dry Type A
article), 50 to
720 mg lasalocid,
and 45 to 180 mg
tylosin/lb to a
ration of
nonmedicated feed..
Lasalocid provided
by No. 054771, and
tylosin provided
by Nos. 000986 and
016592 in Sec.
510.600(c) of this
chapter.(v) [Reserved]...................
(vi)-(vii) [Reserved]...........(viii) 0.25 to 0.5............... Oxytetracycline 75.. Heifers fed in Add at the rate of 054771
confinement for 0.5 to 2.0 lb/head/
slaughter: As in day a medicated
paragraph (e)(1)(i) of feed (liquid or
this section; and for dry) containing
reduction of liver 0.125 to 1.0 mg
condemnation due to melengestrol
liver abscesses.. acetate/lb per
pound to a feed
containing 6 to 10
g oxytetracycline
per ton; or add at
the rate of 0.5 to
2.0 lb/head/day a
dry medicated feed
containing 0.125
to 1.0 mg
melengestrol
acetate plus 37.5
to 150 mg
oxytetracycline/lb
to provide 0.25 to
0.5 mg
melengestrol
acetate and 75 mg
oxytetracycline/
head/day..
Oxytetracycline as
provided by No.
066104 in Sec.
510.600(c) of this
chapter..
(ix) 0.25 to 0.5................. Tylosin 60 to 90.... Heifers fed in To administer 0.25 054771
confinement for to 0.5 mg 000986
slaughter: As in melengestrol 016592
paragraph (e)(1)(i) of acetate with 60 to
this section; and for 90 mg tylosin/head/
reduced incidence of day:.
liver abscesses caused 1. Add 0.5 to 2.0
by F. necrophorum and lb/head/day of a
Actinomyces liquid or dry
(Corynebacterium) medicated feed
pyogenes.. containing 0.125
to 1.0 mg
melengestrol
acetate/lb to a
medicated feed
containing 8 to 10
g tylosin per ton;
or.
2. Add 0.5 to 2.0
lb/head/day of a
liquid or dry
medicated feed
containing 0.125
to 1.0 mg
melengestrol
acetate/lb to 4.5
to 18 pounds of a
dry medicated feed
containing 10 to
40 g tylosin per
ton; or.
3. Add 0.5 to 2.0
lb/head/day of a
liquid or dry
medicated feed
containing 0.125
to 1.0 mg
melengestrol
acetate (from a
dry Type A
article) plus 45
to 180 mg tylosin/
lb to a ration of
nonmedicated feed..
Tylosin provided by
Nos. 000986 and
016592 in Sec.
510.600(c) of this
chapter.(x) 0.25 to 0.5.................. Monensin 50 to 480.. Heifers fed in Add at the rate of 054771
confinement for 0.5 to 2.0 lb/head/ 000986
slaughter: As in day a medicated
paragraph (e)(1)(i) of feed (liquid or
this section; and for dry) containing
the prevention and 0.125 to 1.0 mg
control of coccidiosis melengestrol
due to Eimeria bovis acetate/lb to a
and E. zuernii.. feed containing 10
to 40 g of
monensin per ton
to provide 0.25 to
0.5 mg
melengestrol
acetate/head/day
and 0.14 to 0.42
mg monensin/lb
body weight,
depending on
severity of
coccidiosis
challenge, up to
480 mg monensin/
head/day..
...................
Monensin provided
by No. 000986 in
Sec. 510.600(c)
of this chapter..(xi) 0.25 to 0.5................. Monensin 50 to 480, Heifers fed in Feed continuously 054771
plus tylosin 60 to confinement for as sole ration 016592
90. slaughter: As in (liquid or dry) at
paragraph (e)(1)(i) of a rate of 0.5 to
this section; for the 2.0 lb/head/day to
prevention and control provide 0.25 to
of coccidiosis due to 0.5 mg/head/day
Eimeria bovis and E. melengestrol
zuernii; and for acetate; 0.14 to
reduction of incidence 0.42 mg monensin/
of liver abscesses lb body weight/
caused by day, depending on
Fusobacterium the severity of
necrophorum and the coccidiosis
Arcanobacterium challenge, up to
pyogenes.. 480 mg/head/day;
and 60 to 90 mg/
head/day tylosin.
The melengestrol
acetate portion of
this Type C
medicated feed
must be mixed into
a complete feed
containing 10 to
40 g/ton monensin
and 8 to 10 g/ton
tylosin in the
amount of complete
feed consumed by
an animal per day..
...................
Monensin provided
by No. 000986 and
tylosin provided
by Nos. 000986 and
016592 in Sec.
510.600(c) of this
chapter..----------------------------------------------------------------------------------------------------------------
(2) Melengestrol may also be used with:
(i) Ractopamine as in Sec. 558.500 of this chapter.
(ii) Zilpaterol as in Sec. 558.665 of this chapter. [42 FR 28535, June 3, 1977]
Editorial Note: For Federal Register citations affecting Sec. 558.342, see the List of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at www.fdsys.gov.