(a) Approvals. Type A medicated articles:
(1) 10, 20, 30, 50, 100, and 200 grams per pound to No. 066104 in Sec. 510.600(c) of this chapter.
(2) 50, 100, and 200 grams per pound to No. 069254 in Sec. 510.600(c) of this chapter.
(b) Special considerations. (1) In accordance with Sec. 558.5 labeling shall bear the statement: ``FOR USE IN DRY ANIMAL FEED ONLY. NOT FOR USE IN LIQUID FEED SUPPLEMENTS.''
(1) In accordance with Sec. 558.5 labeling shall bear the statement: ``FOR USE IN DRY ANIMAL FEED ONLY. NOT FOR USE IN LIQUID FEED SUPPLEMENTS.''
(2) The articles in paragraph (a)(1) of this section contain an amount of mono-alkyl (C8-C18) trimethylammonium oxytetracycline expressed in terms of an equivalent amount of oxytetracycline hydrochloride or an amount of oxytetracycline dihydrate base expressed in terms of an equivalent amount of oxytetracycline hydrochloride.
(3) 50-, 100-, and 200-gram per pound articles in paragraph (a)(2) of this section contain oxytetracycline dihydrate expressed in terms of an equivalent amount of oxytetracycline hydrochloride. Another 100-gram per pound article in paragraph (a)(2) of this section contains oxytetracycline hydrochloride.
(c) Related tolerances. See Sec. 556.500 of this chapter.
(d) Conditions of use--(1) Chickens-- ----------------------------------------------------------------------------------------------------------------
(i) 10 to 50 grams per ton (g/ton)....... Chickens: For increased rate Feed continuously; do not 066104,
of weight gain and improved feed to chickens producing 069254
feed efficiency.. eggs for human consumption..----------------------------------------------------------------------------------------------------------------(ii) 100 to 200 g/ton.................... Chickens: For control of Feed continuously for 7 to 066104,
infectious synovitis caused 14 days (d); do not feed to 069254
by Mycoplasma synoviae and chickens producing eggs for
control of fowl cholera human consumption; in low
caused by Pasteurella calcium feeds, withdraw 3 d
multocida susceptible to before slaughter..
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iii) 400 g/ton.......................... Chickens: For control of Feed continuously for 7 to 066104,
chronic respiratory disease 14 d; do not feed to 069254
(CRD) and air sac infection chickens producing eggs for
caused by Mycoplasma human consumption; in low
gallisepticum and calcium feeds, withdraw 3 d
Escherichia coli before slaughter..
susceptible to
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iv) 500 g/ton........................... Chickens: For reduction of Feed continuously for 5 d; 066104,
mortality due to air do not feed to chickens 069254
sacculitis (air sac producing eggs for human
infection) caused by E. consumption; withdraw 24
coli susceptible to hours before slaughter; in
oxytetracycline.. low calcium feeds, withdraw
3 d before slaughter..----------------------------------------------------------------------------------------------------------------
(2) Turkeys-- ----------------------------------------------------------------------------------------------------------------
(i) 10 to 50 g/ton.................. Growing turkeys: For Feed continuously; do not 066104,
increased rate of feed to turkeys 069254
weight gain and producing eggs for human
improved feed consumption..
efficiency..----------------------------------------------------------------------------------------------------------------(ii) 100 g/ton...................... Turkeys: For control of Feed continuously for 7 066104,
hexamitiasis caused by to 14 d; do not feed to 069254
Hexamita meleagridis turkeys producing eggs
susceptible to for human consumption..
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iii) 200 g/ton..................... Turkeys: For control of Feed continuously for 7 066104,
infectious synovitis to 14 d; for No. 066104 069254
caused by M. synoviae withdraw 5 d before
susceptible to slaughter; for No.
oxytetracycline.. 069254 zero-day
withdrawal time; do not
feed to turkeys
producing eggs for human
consumption..----------------------------------------------------------------------------------------------------------------(iv) 25 milligrams/pound (mg/lb) of Turkeys: For control of Feed continuously for 7 066104,
body weight daily. complicating bacterial to 14 d; for No. 066104 069254
organisms associated withdraw 5 d before
with bluecomb slaughter; for No.
(transmissible 069254 zero-day
enteritis; coronaviral withdrawal time; do not
enteritis) susceptible feed to turkeys
to oxytetracycline.. producing eggs for human
consumption..----------------------------------------------------------------------------------------------------------------
(3) Swine-- ----------------------------------------------------------------------------------------------------------------
(i) 10 to 50 g/ton.................. Swine: For increased Feed continuously........ 066104,
rate of weight gain 069254
and improved feed
efficiency..----------------------------------------------------------------------------------------------------------------
(ii) 10 mg/lb of body weight daily.. 1. Swine: For treatment Feed continuously for 7 066104,
of bacterial enteritis to 14 d.. 069254
caused by E. coli and
Salmonella
choleraesuis
susceptible to
oxytetracycline and
treatment of bacterial
pneumonia caused by P.
multocida susceptible
to oxytetracycline..
2. Breeding swine: For Feed continuously for 14 066104,
control and treatment d.. 069254
of leptospirosis
(reducing the
incidence of abortion
and shedding of
leptospirae) caused by
Leptospira pomona
susceptible to
oxytetracycline..----------------------------------------------------------------------------------------------------------------
(4) Cattle-- ----------------------------------------------------------------------------------------------------------------
(i) 0.05 to 0.1 mg/lb of body weight Calves (up to 250 lb): Feed continuously in milk 066104,
daily. For increased rate of replacer or starter 069254
weight gain and feed..
improved feed
efficiency..----------------------------------------------------------------------------------------------------------------(ii) 10 mg/lb of body weight daily.. 1. Calves and beef and Feed continuously for 7 066104,
nonlactating dairy to 14 d; for No. 069254, 069254
cattle: For treatment withdraw 5 d before
of bacterial enteritis slaughter; for No.
caused by E. coli and 066104, zero-day
bacterial pneumonia withdrawal time..
(shipping fever
complex) caused by P.
multocida susceptible
to oxytetracycline..
2. Calves: For Feed continuously for 7 066104,
treatment of bacterial to 14 d in milk replacer 069254
enteritis caused by E. or starter feed; for No.
coli susceptible to 069254, withdraw 5 d
oxytetracycline.. before slaughter; for
No. 066104, zero-day
withdrawal time..----------------------------------------------------------------------------------------------------------------(iii) 25 mg/head/day................ Calves (250 to 400 lb): Feed continuously........ 066104,
For increased rate of 069254
weight gain and
improved feed
efficiency..----------------------------------------------------------------------------------------------------------------(iv) 75 mg/head/day................. Growing cattle (over Feed continuously........ 066104,
400 lb): For increased 069254
rate of weight gain,
improved feed
efficiency, and
reduction of liver
condemnation due to
liver abscesses..----------------------------------------------------------------------------------------------------------------(v) 0.5 to 2.0 g/head/day........... Cattle: For prevention Feed 3 to 5 d before and 066104,
and treatment of the after arrival in 069254
early stages of feedlots..
shipping fever
complex..----------------------------------------------------------------------------------------------------------------
(5) Minor species-- ----------------------------------------------------------------------------------------------------------------
(i) 10 to 20 g/ton.................. Sheep: For increased Feed continuously........ 066104,
rate of weight gain 069254
and improved feed
efficiency..----------------------------------------------------------------------------------------------------------------(ii) 10 mg/lb of body weight daily.. Sheep: For treatment of Feed continuously for 7 066104,
bacterial enteritis to 14 d; withdraw 5 d 069254
caused by E. coli and before slaughter..
bacterial pneumonia
caused by P. multocida
susceptible to
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iii) 200 mg/colony................. Honey bees: For control Remove at least 6 weeks 066104,
of American foulbrood prior to main honey 069254
caused by flow..
Paenibacillus larvae
and European foulbrood
caused by
Streptococcus pluton
susceptible to
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iv) 250 mg/kilogram of fish/day Pacific salmon: For For salmon not over 30 g 066104
(11.35 g/100 lb of fish/day). marking of skeletal body weight; administer
tissue.. as sole ration for 4
consecutive days; fish
not to be liberated for
at least 7 d following
the last administration
of medicated feed..----------------------------------------------------------------------------------------------------------------(v) 2.5 to 3.75 g/100 lb of fish/day 1. Salmonids: For Administer in mixed 066104
control of ulcer ration for 10 d; do not
disease caused by liberate fish or
Hemophilus piscium, slaughter fish for food
furunculosis caused by for 21 d following the
Aeromonas salmonicida, last administration of
bacterial hemorrhagic medicated feed..
septicemia caused by
A. liquefaciens, and
pseudomonas disease..
2. Catfish: For control Administer in mixed 066104
of bacterial ration for 10 d; do not
hemorrhagic septicemia liberate fish or
caused by A. slaughter fish for food
liquefaciens and for 21 d following the
pseudomonas disease.. last administration of
medicated feed; do not
administer when water
temperature is below
16.7 [deg]C (62 [deg]F)..----------------------------------------------------------------------------------------------------------------(vi) 3.75 g/100 lb of fish/day...... 1. Freshwater-reared Administer in mixed 066104
salmonids: For control ration for 10 d; do not
of mortality due to liberate fish or
coldwater disease slaughter fish for food
associated with for 21 d following the
Flavobacterium last administration of
psychrophilum.. medicated feed..
2. Freshwater-reared Administer in mixed 066104
Oncorhynchus mykiss: ration for 10 d; do not
For control of liberate fish or
mortality due to slaughter fish for food
columnaris disease for 21 d following the
associated with last administration of
Flavobacterium medicated feed..
columnare..----------------------------------------------------------------------------------------------------------------(vii) 1 g/lb of medicated feed...... Lobsters: For control Administer as sole ration 066104
of gaffkemia caused by for 5 consecutive days;
Aerococcus viridans.. withdraw medicated feed
30 d before harvesting
lobsters..----------------------------------------------------------------------------------------------------------------
(6) Oxytetracycline may be used in accordance with the provisions of this section in the combinations as follows:
(i) Carbadox as in Sec. 558.115.
(ii) Lasalocid as in Sec. 558.311.
(iii) Melengestrol acetate as in Sec. 558.342.
(iv) Robenidine hydrochloride as in Sec. 558.515.
(v) Salinomycin as in Sec. 558.550. [61 FR 51590, Oct. 3, 1996, as amended at 63 FR 41192, Aug. 3, 1998; 66 FR 32740, June 18, 2001; 66 FR 45167, Aug. 28, 2001; 66 FR 47963, Sept. 17, 2001; 67 FR 51081, Aug. 7, 2002; 69 FR 28821, May 19, 2004; 69 FR 51173, Aug. 18, 2004; 69 FR 62407, Oct. 26, 2004; 71 FR 27958, May 15, 2006; 71 FR 44887, Aug. 8, 2006; 71 FR 53006, Sept. 8, 2006; 72 FR 70774, Dec. 13, 2007; 73 FR 45875, Aug. 7, 2008; 80 FR 13232, Mar. 13, 2015]