(a) Specifications. Type A medicated articles containing oxytetracycline equivalent to 50 grams per pound (g/lb) oxytetracycline hydrochloride and 50 g/lb neomycin sulfate or oxytetracycline equivalent to 100 g/lb oxytetracycline hydrochloride and 100 g/lb neomycin sulfate.
(b) Sponsors. See Nos. 066104 and 069254 in Sec. 510.600(c) of this chapter.
(c) Related tolerances. See Sec. Sec. 556.430 and 556.500 of this chapter.
(d) Special considerations. Cattle feeds shall bear the following warning statement: ``Use of more than one product containing neomycin or failure to follow withdrawal times may result in illegal drug residues.''
(e) Indications for use--(1) Chickens. It is used in feed as follows: ----------------------------------------------------------------------------------------------------------------
Oxytetracycline and neomycin sulfate
(i) 10 to 50............................. Chickens: For increased rate Feed continuously; do not 066104
of weight gain and improved feed to chickens producing 069254
feed efficiency.. eggs for human consumption;
in low calcium feeds
withdraw 3 days before
slaughter..----------------------------------------------------------------------------------------------------------------(ii) 100 to 200.......................... Chickens: For control of Feed continuously for 7 to 066104
infectious synovitis caused 14 d; do not feed to 069254
by Mycoplasma synoviae; chickens producing eggs for
control of fowl cholera human consumption; in low
caused by Pasteurella calcium feed, withdraw 3 d
multocida susceptible to before slaughter..
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iii) 400................................ Chickens: For control of Feed continuously for 7 to 066104
chronic respiratory disease 14 d; do not feed to 069254
(CRD) and air sac infection chickens producing eggs for
caused by M. gallisepticum human consumption; in low
and Escherichia coli calcium feeds, withdraw 3 d
susceptible to before slaughter..
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iv) 500................................. Chickens: For reduction of Feed continuously for 5 d; 066104
mortality due to air do not feed to chickens 069254
sacculitis (air-sac- producing eggs for human
infection) caused by E. consumption; withdraw 24
coli susceptible to hours before slaughter; in
oxytetracycline.. low calcium feeds withdraw
3 d before slaughter..----------------------------------------------------------------------------------------------------------------
(2) Turkeys. It is used in feed as follows: ----------------------------------------------------------------------------------------------------------------
Oxytetracycline and neomycin sulfate
(i) 10 to 50 grams per ton (g/ton) of Growing turkeys: For Feed continuously; do not 066104
feed. increased rate of weight feed to turkeys producing 069254
gain and improved feed eggs for human consumption..
efficiency..----------------------------------------------------------------------------------------------------------------(ii) 100 g/ton of feed................... Turkeys: For control of Feed continuously for 7 to 066104
hexamitiasis caused by 14 d; do not feed to 069254
Hexamita meleagridis turkeys producing eggs for
susceptible to human consumption..
oxytetracycline..----------------------------------------------------------------------------------------------------------------(iii) 200 g/ton of feed.................. Turkeys: For control of Feed continuously for 7 to 066104
infectious synovitis caused 14 d; withdraw 5 d before 069254
by M. synoviae susceptible slaughter; do not feed to
to oxytetracycline.. turkeys producing eggs for
human consumption..----------------------------------------------------------------------------------------------------------------(iv) To provide 25 milligrams per pound Turkeys: For control of Feed continuously for 7 to 066104
(mg/lb) of body weight daily.. complicating bacterial 14 d; withdraw 5 d before 069254
organisms associated with slaughter; do not feed to
bluecomb (transmissible turkeys producing eggs for
enteritis; coronaviral human consumption..
enteritis) susceptible to
oxytetracycline..----------------------------------------------------------------------------------------------------------------
(3) Swine. It is used in feed as follows: ----------------------------------------------------------------------------------------------------------------
Oxytetracycline and neomycin sulfate
(i) 10 to 50 g/ton of feed............... Swine: For increased rate of Feed continuously........... 066104
weight gain and improved 069254
feed efficiency..----------------------------------------------------------------------------------------------------------------(ii) To provide 10 mg/lb of body weight 1. Swine: For treatment of Feed continuously for 7 to 066104
daily.. bacterial enteritis caused 14 d; withdraw 5 d before 069254
by E. coli and Salmonella slaughter..
choleraesuis and treatment
of bacterial pneumonia
caused by P. multocida
susceptible to
oxytetracycline; treatment
and control of
colibacillosis (bacterial
enteritis) caused by E.
coli susceptible to
neomycin..
2. Breeding swine: For Feed continuously for not 066104
control and treatment of more than 14 d; withdraw 5 069254
leptospirosis (reducing the d before slaughter..
incidence of abortion and
shedding of leptospirae)
caused by Leptospira pomona
susceptible to
oxytetracycline..----------------------------------------------------------------------------------------------------------------
(4) Cattle and sheep. It is used in feed as follows: ----------------------------------------------------------------------------------------------------------------
Oxytetracycline and neomycin sulfate
(i) 10 to 20 g/ton of feed............... Sheep: For increased rate of Feed continuously........... 066104
weight gain and improved 069254
feed efficiency..----------------------------------------------------------------------------------------------------------------(ii) To provide 0.05 to 0.1 mg/lb of body Calves (up to 250 lb): For Feed continuously; in milk 066104
weight daily.. increased rate of weight replacers or starter feed.. 069254
gain and improved feed
efficiency..----------------------------------------------------------------------------------------------------------------(iii) To provide 10 mg/lb of body weight 1. Calves and beef and Feed continuously for 7 to 066104
daily.. nonlactating dairy cattle: 14 d; in feed or milk 069254
For treatment of bacterial replacers. If symptoms
enteritis caused by E. coli persist after using for 2
and bacterial pneumonia or 3 days, consult a
(shipping fever complex) veterinarian. Treatment
caused by P. multocida should continue 24 to 48
susceptible to hours beyond remission of
oxytetracycline; treatment disease symptoms. A
and control of withdrawal period has not
colibacillosis (bacterial been established for use in
enteritis) caused by E. preruminating calves. Do
coli susceptible to not use in calves to be
neomycin.. processed for veal. A milk
discard time has not been
established for use in
lactating dairy cattle. Do
not use in female dairy
cattle 20 months of age or
older. Withdraw 5 d before
slaughter..
2. Calves (up to 250 lb): Feed continuously for 7 to 066104
For treatment of bacterial 14 d; in milk replacers or 069254
enteritis caused by E. coli starter feed. If symptoms
susceptible to persist after using for 2
oxytetracycline; treatment or 3 days, consult a
and control of veterinarian. Treatment
colibacillosis (bacterial should continue 24 to 48
enteritis) caused by E. hours beyond remission of
coli susceptible to disease symptoms. A
neomycin.. withdrawal period has not
been established for use in
preruminating calves. Do
not use in calves to be
processed for veal. A milk
discard time has not been
established for use in
lactating dairy cattle. Do
not use in female dairy
cattle 20 months of age or
older. Withdraw 5 d before
slaughter..
3. Sheep: For treatment of Feed continuously for 7 to 066104
bacterial enteritis caused 14 d. If symptoms persist 069254
by E. coli and bacterial after using for 2 or 3
pneumonia caused by P. days, consult a
multocida susceptible to veterinarian. Treatment
oxytetracycline; treatment should continue 24 to 48
and control of hours beyond remission of
colibacillosis (bacterial disease symptoms. Withdraw
enteritis) caused by E. 5 d before slaughter..
coli susceptible to
neomycin..----------------------------------------------------------------------------------------------------------------(iv) To provide 25 mg/head/day........... Calves (250 to 400 lb): For Feed continuously........... 066104
increased rate of weight 069254
gain and improved feed
efficiency..----------------------------------------------------------------------------------------------------------------
(v) To provide 75 mg/head/day............ Growing cattle (over 400 Feed continuously........... 066104
lb): For increased rate of 069254
weight gain; improved feed
efficiency, and reduction
of liver condemnation due
to liver abscesses..----------------------------------------------------------------------------------------------------------------(vi) To provide 0.5 to 2.0 g/head/ day... Cattle: For prevention and Feed 3 to 5 d before and 066104
treatment of the early after arrival in feedlots. 069254
stages of shipping fever A withdrawal period has not
complex.. been established for use in
preruminating calves. Do
not use in calves to be
processed for veal. A milk
discard time has not been
established for use in
lactating dairy cattle. Do
not use in female dairy
cattle 20 months of age or
older..---------------------------------------------------------------------------------------------------------------- [71 FR 16225, Mar. 31, 2006, as amended at 74 FR 40724, Aug. 13, 2009; 80 FR 13232, Mar. 13, 2015]