Code of Federal Regulations (alpha)

CFR /  Title 21  /  Part 558  /  Sec. 558.500 Ractopamine.

(a) Specifications. Type A medicated articles containing 9 or 45.4 grams of ractopamine hydrochloride per pound.

(b) Approvals. See Nos. 000986 and 054771 in Sec. 510.600(c) of this chapter.

(c) Related tolerances. See Sec. 556.570 of this chapter.

(d) Special considerations. (1) Labeling of Type B and Type C feeds shall bear the following: ``Not for animals intended for breeding.''

(1) Labeling of Type B and Type C feeds shall bear the following: ``Not for animals intended for breeding.''

(2) Labeling of Type B and Type C swine feeds shall bear the following:

(i) ``No increased benefit has been shown when ractopamine concentrations in the diet are greater than 4.5 g/ton.''

(ii) ``Ractopamine may increase the number of injured and/or fatigued pigs during marketing.''

(3) Labeling of Type B and Type C tom turkey feeds shall bear the following: ``No increased benefit has been shown when ractopamine concentrations in the diet are greater than 4.6 g/ton.''

(4) Tylosin in combinations as tylosin phosphate.

(5) Ractopamine liquid Type B cattle feeds may be manufactured from dry ractopamine Type A articles. The liquid Type B feeds must be maintained at a pH of 4.5 to 7.5 or, if in combination with monensin and/or tylosin, at a pH of 4.5 to 6.0. Mixing directions for liquid Type B feeds requiring recirculation or agitation: Recirculate immediately prior to use for not less than 10 minutes, moving not less than 1 percent of the tank contents per minute from the bottom of the tank to the top. Recirculate daily as described even when not used.

(e) Conditions of use--(1) Swine-- ----------------------------------------------------------------------------------------------------------------

Combination in grams/

(i) 4.5 to 9.0................... .................... For increased rate of Feed continuously 000986,

weight gain, improved as sole ration. 054771

feed efficiency, and

increased carcass

leanness in finishing

swine, weighing not

less than 150 lbs, fed

a complete ration

containing at least

16% crude protein for

the last 45 to 90 lbs

of gain prior to

slaughter.(ii) 4.5 to 9.0.................. Tylosin............. Finishing swine: As in Feed 100 grams per 000986,

40 or 100........... paragraph (e)(1)(i) of tons (g/ton) 016592,

this section; and for continuously as 054771

control of swine sole ration for at

dysentery associated least 3 weeks

with Brachyspira followed by 40 g/

hyodysenteriae and ton until market

porcine proliferative weight.

enteropathies (PPE, Ractopamine as

ileitis) associated provided by No.

with Lawsonia 000986 with

intracellularis.. tylosin as

provided by Nos.

000986 or 016592

in Sec.

510.600(c) of this

chapter; or

ractopamine as

provided by No.

054771 with

tylosin as

provided by No.

000986 in Sec.

510.600(c) of this

chapter..(iii) 4.5 to 9.0................. Tylosin............. Finishing swine: As in Feed continuously 000986,

100................. paragraph (e)(1)(i) of as sole ration for 016592,

this section; and for 21 days. 054771

control of porcine Ractopamine as

proliferative provided by No.

enteropathies (PPE, 000986 with

ileitis) associated tylosin as

with L. provided by Nos.

intracellularis.. 000986 or 016592

in Sec.

510.600(c) of this

chapter; or

ractopamine as

provided by No.

054771 with

tylosin as

provided by No.

000986 in Sec.

510.600(c) of this

chapter..(iv) 4.5 to 9.0.................. Tylosin............. Finishing swine: As in Feed continuously 000986,

40 to 100........... paragraph (e)(1)(i) of as sole ration for 016592,

this section; for 2 to 6 weeks, 054771

treatment and control immediately after

of swine dysentery treatment with

associated with B. tylosin tartrate

hyodysenteriae and for in drinking water

control of porcine as in Sec.

proliferative 520.2640(d)(3) of

enteropathies (PPE, this chapter.

ileitis) associated Ractopamine as

with L. provided by No.

intracellularis.. 000986 with

tylosin as

provided by Nos.

000986 or 016592

in Sec.

510.600(c) of this

chapter; or

ractopamine as

provided by No.

054771 with

tylosin as

provided by No.

000986 in Sec.

510.600(c) of this

chapter..----------------------------------------------------------------------------------------------------------------

(2) Cattle-- ----------------------------------------------------------------------------------------------------------------

Combination in grams/

(i) 8.2 to 24.6.................. .................... Cattle fed in Feed continuously 000986,

confinement for as sole ration 054771

slaughter: For during the last 28

increased rate of to 42 days on

weight gain and feed..

improved feed

efficiency during the

last 28 to 42 days on

feed.(ii) 8.2 to 24.6................. Monensin 10 to 40 to Cattle fed in As in paragraph 000986,

provide 0.14 to confinement for (e)(2)(i) of this 054771

0.42 mg monensin/lb slaughter: As in section; see

of body weight, paragraph (e)(2)(i) of paragraph Sec.

depending on this section; for 558.355(d) of this

severity of prevention and control chapter.

coccidiosis of coccidiosis due to Ractopamine as

challenge, up to Eimeria bovis and E provided by Nos.

480 mg/head/day. zuernii. 000986 or 054771

in Sec.

510.600(c) of this

chapter; monensin

as provided by No.

000986 in Sec.

510.600(c) of this

chapter.(iii) [Reserved].................(iv) 8.2 to 24.6................. Monensin 10 to 40 to Cattle fed in As in paragraph 000986,

provide 0.14 to confinement for (e)(2)(i) of this 016592,

0.42 mg monensin/lb slaughter: As in section; see Sec. 054771

of body weight, paragraph (e)(2)(i) of Sec. 558.355(d)

depending on this section; for and 558.625(c) of

severity of prevention and control this chapter.

coccidiosis of coccidiosis due to Ractopamine as

challenge, up to Eimeria bovis and E provided by No.

480 mg/head/day, zuernii; and for 000986 with

plus tylosin 8 to reduction of incidence tylosin as

10. of liver abscesses provided by Nos.

caused by 000986 or 016592

Fusobacterium in Sec.

necrophorum and 510.600(c) of this

Arcanobacterium chapter; or

(Actinomyces) pyogenes. ractopamine as

provided by No.

054771 with

tylosin as

provided by No.

000986 in Sec.

510.600(c) of this

chapter.(v) [Reserved]...................(vi) 9.8 to 24.6................. .................... Cattle fed in Feed continuously 000986,

confinement for as sole ration 054771

slaughter: For during the last 28

increased rate of to 42 days on

weight gain, improved feed. Not for

feed efficiency, and animals intended

increased carcass for breeding.

leanness during the

last 28 to 42 days on

feed.(vii) 9.8 to 24.6................ Monensin 10 to 40 to Cattle fed in As in paragraph 000986,

provide 0.14 to confinement for (e)(2)(vi) of this 054771

0.42 mg monensin/lb slaughter: As in section; see

of body weight, paragraph (e)(2)(vi) paragraph Sec.

depending on of this section; for 558.355(d) of this

severity of prevention and control chapter.

coccidiosis of coccidiosis due to Ractopamine as

challenge, up to Eimeria bovis and E provided by Nos.

480 mg/head/day. zuernii. 000986 or 054771

in Sec.

510.600(c) of this

chapter; monensin

as provided by No.

000986 in Sec.

510.600(c) of this

chapter.(viii) 9.8 to 24.6............... Monensin 10 to 40 to Heifers fed in As in paragraph 000986,

provide 0.14 to confinement for (e)(2)(vi) of this 054771

0.42 mg monensin/lb slaughter: As in section; see Sec.

of body weight, paragraph (e)(2)(vi) Sec. 558.342(d)

depending on of this section; for and 558.355(d) of

severity of prevention and control this chapter.

coccidiosis of coccidiosis due to Melengestrol

challenge, up to Eimeria bovis and E. acetate as

480 mg/head/day, zuernii; and for provided by Nos.

plus melengestrol suppression of estrus 000986 and 054771

acetate to provide (heat).. or 021641 in Sec.

0.25 to 0.5 mg/head/ 510.600(c) of

day. this chapter..(ix) 9.8 to 24.6................. Monensin 10 to 40 to Cattle fed in As in paragraph 000986,

provide 0.14 to confinement for (e)(2)(vi) of this 016592,

0.42 mg monensin/lb slaughter: As in section; see Sec. 054771

of body weight, paragraph (e)(2)(vi) Sec. 558.355(d)

depending on of this section; for and 558.625(c) of

severity of prevention and control this chapter.

coccidiosis of coccidiosis due to Ractopamine and

challenge, up to Eimeria bovis and E monensin as

480 mg/head/day, zuernii; and for provided by No.

plus tylosin 8 to reduction of incidence 000986 with

10. of liver abscesses tylosin as

caused by provided by Nos.

Fusobacterium 000986 or 016592

necrophorum and in Sec.

Arcanobacterium 510.600(c) of this

(Actinomyces) pyogenes. chapter; or

ractopamine as

provided by No.

054771 with

monensin and

tylosin as

provided by No.

000986 in Sec.

510.600(c) of this

chapter.

(x) 9.8 to 24.6.................. Monensin 10 to 40 to Heifers fed in As in paragraph 000986,

provide 0.14 to confinement for (e)(2)(vi) of this 016592,

0.42 mg monensin/lb slaughter: As in section; see 054771

of body weight, paragraph (e)(2)(vi) paragraphs Sec.

depending on of this section; for Sec. 558.342(d),

severity of prevention and control 558.355(d) and

coccidiosis of coccidiosis due to 558.625(c) of this

challenge, up to Eimeria bovis and E chapter.

480 mg/head/day, zuernii; for reduction Ractopamine,

plus tylosin 8 to of incidence of liver monensin, and

10, plus abscesses caused by tylosin as

melengestrol Fusobacterium provided by No.

acetate to provide necrophorum and 000986 with

0.25 to 0.5 mg/head/ Arcanobacterium melengestrol

day. (Actinomyces) acetate as

pyogenes; and for provided by Nos.

suppression of estrus 000986 or 054771

(heat). in Sec.

510.600(c) of this

chapter; or

ractopamine and

monensin as

provided by No.

000986 with

tylosin as

provided by Nos.

000986 or 016592

and melengestrol

acetate as

provided by No.

054771 in Sec.

510.600(c) of this

chapter; or

ractopamine as

provided by No.

054771 with

monensin and

tylosin as

provided by No.

000986 and

melengestrol

acetate provided

by No. 054771 in

Sec. 510.600(c)

of this chapter.(xi) Not to exceed 800; to .................... Cattle fed in Top dress in a 000986,

provide 70 to 400 mg/head/day.. confinement for minimum of 1.0 lb 054771

slaughter: As in of medicated feed..

paragraph (e)(2)(i) of

this section..(xii) Not to exceed 800; to Monensin 10 to 40 to Cattle fed in Top dress 000986,

provide 70 to 400 mg/head/day. provide 0.14 to confinement for ractopamine in a 054771

0.42 mg monensin/lb slaughter: As in minimum of 1.0 lb

of body weight, paragraph (e)(2)(i) of of medicated feed

depending on this section; for during the last 28

severity of prevention and control to 42 days on

coccidiosis of coccidiosis due to feed. Not for

challenge, up to Eimeria bovis and E animals intended

480 mg/head/day. zuernii. for breeding. See

Sec. 558.355(d).

Ractopamine as

provided by Nos.

000986 or 054771

in Sec.

510.600(c) of this

chapter; monensin

as provided by No.

000986 in Sec.

510.600(c) of this

chapter.(xiii) Not to exceed 800; to Monensin 10 to 40 to Cattle fed in Top dress 000986,

provide 70 to 400 mg/head/day. provide 0.14 to confinement for ractopamine in a 016592,

0.42 mg monensin/lb slaughter: As in minimum of 1.0 lb 054771

of body weight, paragraph (e)(2)(i) of of medicated feed

depending on this section; for during the last 28

severity of prevention and control to 42 days on

coccidiosis of coccidiosis due to feed. Not for

challenge, up to Eimeria bovis and E animals intended

480 mg/head/day, zuernii; and for for breeding. See

plus tylosin 8 to reduction of incidence Sec. Sec.

10. of liver abscesses 558.355(d) and

caused by 558.625(c).

Fusobacterium Ractopamine and

necrophorum and monensin as

Arcanobacterium provided by No.

(Actinomyces) pyogenes. 000986 with

tylosin as

provided by Nos.

000986 or 016592

in Sec.

510.600(c) of this

chapter; or

ractopamine as

provided by No.

054771 with

monensin and

tylosin as

provided by No.

000986 in Sec.

510.600(c) of this

chapter.----------------------------------------------------------------------------------------------------------------

(3) Turkeys-- ----------------------------------------------------------------------------------------------------------------

Combination in grams/

(i) 4.6 to 11.8 (5 to 13 ppm).... .................... Finishing hen turkeys: Feed continuously 000986

For increased rate of as sole ration

weight gain and during the last 7

improved feed to 14 days prior

efficiency when fed to slaughter..

for the last 7 to 14

days prior to

slaughter..----------------------------------------------------------------------------------------------------------------

(ii) 4.6 to 11.8 (5 to 13 ppm)... .................... Finishing tom turkeys: Feed continuously 000986

For increased rate of as sole ration

weight gain and during the last 14

improved feed days prior to

efficiency when fed slaughter. Feeding

for the last 14 days ractopamine to tom

prior to slaughter.. turkeys during

periods of

excessive heat can

result in

increased

mortality..(iii) 4.6 to 11.8 (5 to 13 ppm).. Monensin 54 to 90... Finishing hen turkeys: Feed continuously 000986

As in paragraph as sole ration

(e)(3)(i) of this during the last 7

(3)(i) of this during the last 7

(i) of this during the last 7

section; and for the to 14 days prior

prevention of to slaughter. See

coccidiosis in growing Sec. 558.355(d)..

turkeys caused by

Eimeria adenoeides, E.

meleagrimitis and E.

gallopavonis..(iv) 4.6 to 11.8 (5 to 13 ppm)... Monensin 54 to 90... Finishing tom turkeys: Feed continuously 000986

As in paragraph as sole ration

(e)(3)(ii) of this during the last 14

(3)(ii) of this during the last 14

(ii) of this during the last 14

section; and for the days prior to

prevention of slaughter. Feeding

coccidiosis in growing ractopamine to tom

turkeys caused by turkeys during

Eimeria adenoeides, E. periods of

meleagrimitis and E. excessive heat can

gallopavonis.. result in

increased

mortality. See

Sec. 558.355(d)..---------------------------------------------------------------------------------------------------------------- [67 FR 71820, Dec. 3, 2002, as amended at 68 FR 54659, Sept. 18, 2003; 69 FR 12068, Mar. 15, 2004; 69 FR 51174, Aug. 18, 2004; 71 FR 31074, June 1, 2006; 71 FR 67301, Nov. 21, 2006; 72 FR 10358, Mar. 8, 2007; 72 FR 41619, July 31, 2007; 72 FR 56897, Oct. 5, 2007; 72 FR 62571, Nov. 6, 2007; 72 FR 65667, Nov. 23, 2007; 72 FR 70777, Dec. 13, 2007; 73 FR 72715, Dec. 1, 2008; 73 FR 75323, Dec. 11, 2008; 74 FR 66914, Dec. 17, 2009; 75 FR 1276, Jan. 11, 2010; 75 FR 5888, Feb. 5, 2010; 75 FR 20917, Apr. 22, 2010; 75 FR 54018, Sept. 3, 2010; 77 FR 31724, May 30, 2012; 78 FR 63872, Oct. 25, 2013; 79 FR 13546, Mar. 11, 2014; 79 FR 37621, July 2, 2014; 79 FR 44278, July 31, 2014; 79 FR 53136, Sept. 8, 2014]