Code of Federal Regulations (alpha)

CFR /  Title 40  /  Part 721  /  Sec. 721.1660 Benzidine-based chemical substances.

(a) Chemical substances and significant new uses subject to reporting. (1) The benzidine-based chemical substances listed in Table 1 and Table 2 of this section are subject to reporting under this section for the significant new uses described in paragraph (a)(2) of this section.

Table 1--Benzidine-Based Chemical Substances----------------------------------------------------------------------------------------------------------------

CAS or accession No. C.I. name C.I. No. Chemical name----------------------------------------------------------------------------------------------------------------117-33-9..................... Not available... Not available.. 1,3-Naphthalenedisulfonic acid, 7-hydroxy-8-[2-

[4'-[2-(4-hydroxyphenyl)diazenyl][1,1'-

biphenyl]-4-yl]diazenyl]-65150-87-0................... Not available... Not available.. 1,3,6-Naphthalenetrisulfonic acid, 8-hydroxy-7-

[2-[4'-[2-(2-hydroxy-1-

naphthalenyl)diazenyl][1,1'- biphenyl]-4-

yl]diazenyl]-, lithium salt (1:3)68214-82-4................... Direct Navy BH.. 22590.......... 2,7-Naphthalenedisulfonic acid, 5-amino-3-[2-

[4'-[2-(7-amino-1-hydroxy-3-sulfo-2-

naphthalenyl)diazenyl][1,1'-biphenyl]-4-

yl]diazenyl]-4-hydroxy-, sodium salt (1:2)72379-45-4................... Not available... Not available.. 2,7-Naphthalenedisulfonic acid, 4-amino-5-

hydroxy-3-[2-[4'-[2-[2-hydroxy-4-[(2-

methylphenyl)amino]phenyl]diazenyl][1,1'-

biphenyl]-4-yl]diazenyl]-6-(2-phenyldiazenyl)-

Accession No. 21808.......... CBI............. CBI............ 2,7-Naphthalenedisulfonic acid, 4-amino-5-CAS No. CBI (NA)............. hydroxy [[[(substituted phenylamino)]

substituted phenylazo] diphenyl]azo-,

phenylazo-, disodium salt. (generic name)Accession No. 24921.......... CBI............. CBI............ 4-(Substituted naphthalenyl )azo diphenylylCAS No....................... azo-substituted carbopolycycle azo

benzenesulfonic acid, sodium salt. (generic

name)Accession No. 26256.......... CBI............. CBI............ 4-(Substituted phenyl)azo biphenylyl azo-CAS No. CBI (NA)............. substituted carbopolycycloazo benzenesulfonic

acid, sodium salt. (generic name)Accession No. 26267.......... CBI............. CBI............ 4-(Substituted phenyl)azo biphenylyl azo -CAS No. CBI (NA)............. substituted carbopolycycle azo benzenesulfonic

acid, sodium salt. (generic name)Accession No. 26701.......... CBI............. CBI............ PhenylazoaminohydroxynaphthalenylazobiphenylazCAS No. CBI (NA)............. o substituted benzene sodium sulfonate.

(generic name).----------------------------------------------------------------------------------------------------------------

Table 2--Benzidine-Based Chemical Substances----------------------------------------------------------------------------------------------------------------

CAS No. C.I. name C.I. No. Chemical name----------------------------------------------------------------------------------------------------------------92-87-5.......................... Benzidine........... Not available....... [1,1[min]-Biphenyl]-4,4[min]-

diamine.531-85-1......................... Benzidine [middot] Not available....... [1,1[min]-Biphenyl]-4,4[min]-

2HCl. diamine, dihydrochloride.573-58-0......................... C.I. Direct Red 28.. 22120............... 1- Naphthalenesulfonic acid,

3,3[min]-[[1,1[min]-biphenyl]-

4,4[min]-diylbis(azo)]bis[4-

amino-, disodium salt.1937-37-7........................ C.I. Direct Black 38 30235............... 2,7-Naphthalenedisulfonic acid, 4-

amino-3-[[4[min]-[(2,4-

diaminophenyl) azo][1,1[min]-

biphenyl]-4- yl]azo]-5-hydroxy-6-

(phenylazo)-, disodium salt.2302-97-8........................ C.I. Direct Red 44.. 22500............... 1-Naphthalenesulfonic acid,

8,8[min]-[[1,1[min]-biphenyl]-

4,4[min]-diylbis(azo)]bis[7-

hydroxy-, disodium salt.2429-73-4........................ C.I. Direct Blue 2.. 22590............... 2,7-Naphthalenedisulfonic acid, 5-

amino-3-[[4[min]-[(7-amino-1-

hydroxy-3-sulfo-2-

naphthalenyl)azo][1,1[min]-

biphenyl]-4-yl]azo]-4-hydroxy-,

trisodium salt.2429-79-0........................ C.I. Direct Orange 8 22130............... Benzoic acid, 5-[[4[min]-[(1-

amino-4-sulfo-2-naphthalenyl)

azo][1,1[min]-biphenyl]-4-

yl]azo]-2- hydroxy-, disodium

salt.2429-81-4........................ C.I. Direct Brown 31 35660............... Benzoic acid, 5-[[4[min]-[[2,6-

diamino-3-[[8-hydroxy-3,6-

disulfo-7-[(4-sulfo-1-

naphthalenyl)azo]-2-

naphthalenyl]azo]-5-

methylphenyl]azo][1,1[min]-

biphenyl]-4-yl]azo]-2-hydroxy-,

tetrasodium salt.2429-82-5........................ C.I. Direct Brown 2. 22311............... Benzoic acid, 5-[[4[min]-[(7-

amino-1-hydroxy-3-sulfo-2-

naphthalenyl) azo][1,1[min]-

biphenyl]-4-yl]azo]-2-hydroxy-,

disodium salt.2429-83-6........................ Direct Black 4...... 30245............... 2,7-Naphthalenedisulfonic acid, 4-

amino-3-[[4[min]-[(2,4-diamino-5-

methylphenyl)azo][1,1[min]-

biphenyl]-4-yl]azo] -5-hydroxy-6-

(phenylazo)-, disodium salt.

2429-84-7........................ C.I. Direct Red 1... 22310............... Benzoic acid, 5-[[4[min]-[(2-

amino-8-hydroxy-6-sulfo-1-

naphthalenyl)azo][1,1[min]-

biphenyl]-4-yl]azo]-2-hydroxy-,

disodium salt.2586-58-5........................ C.I. Direct Brown 30110............... Benzoic acid, 5-[[4[min]-[[2,6-

1:2. diamino-3-methyl-5-[(4-

sulfophenyl)azo]phenyl]azo][1,1[

min]-biphenyl]-4- yl]azo]-2-

hydroxy-, disodium salt.2602-46-2........................ C.I. Direct Blue 6.. 22610............... 2,7-Naphthalenedisulfonic acid,

3,3[min]-[[1,1[min]-biphenyl]-

4,4[min]-diylbis(azo)]bis[5-

amino-4-hydroxy-, tetrasodium

salt.2893-80-3........................ C.I. Direct Brown 6. 30140............... Benzoic acid, 5-[[4[min]-[[2,4-

dihydroxy-3-[(4-sulfophenyl)

azo]phenyl]azo][1,1[min]-

biphenyl]-4- yl]azo]-2-hydroxy-,

disodium salt.3530-19-6........................ C.I. Direct Red 37.. 22240............... 1,3-Naphthalenedisulfonic acid, 8-

[[4[min]-[(4-

ethoxyphenyl)azo][1,1[min]-

biphenyl]-4-yl]azo]-7-hydroxy-,

disodium salt3567-65-5........................ C.I. Acid Red 85.... 22245............... 1,3-Naphthalenedisulfonic acid, 7-

hydroxy-8-[[4[min]-[[4-[[(4-

methylphenyl)sulfonyl]oxy]phenyl

]azo][1,1[min]-biphenyl]-4-

yl]azo]-, disodium salt.3626-28-6........................ C.I. Direct Green 1. 30280............... 2,7-Naphthalenedisulfonic acid, 4-

amino-5-hydroxy-3-[[4[min]-[(4-

hydroxyphenyl)azo][1,1[min]-

biphenyl]-4- yl]azo]-6-

(phenylazo)-, disodium salt.3811-71-0........................ C.I. Direct Brown 1. 30045............... Benzoic acid, 5-[[4[min]-[[2,4-

diamino-5-[(4-sulfophenyl)

azo]phenyl]azo][1,1[min]

biphenyl]-4- yl]azo]-2-hydroxy-,

disodium salt.4335-09-5........................ C.I. Direct Green 6. 30295............... 2,7-Naphthalenedisulfonic acid, 4-

amino-5-hydroxy-6-[[4[min]-[(4-

hydroxyphenyl)azo][1,1[min]-

biphenyl]-4- yl]azo]-3-[(4-

nitrophenyl)azo]-, disodium

salt.6358-80-1........................ C.I. Acid Black 94.. 30336............... 2,7-Naphthalenedisulfonic acid, 4-

amino-5-hydroxy-3-[[4[min]-[[4-

hydroxy-2-[(2-

methylphenyl)amino]phenyl]azo]

[1,1[min]- biphenyl]-4-yl]azo]-6-

[(4-sulfophenyl) azo]-,

trisodium salt.6360-29-8........................ C.I. Direct Brown 27 31725............... Benzoic acid, 5-[[4[min]-[[4-[(4-

amino-7-sulfo-1-

naphthalenyl)azo]-6-sulfo-1-

naphthalenyl]azo][1,1[min]-

biphenyl]-4-yl] azo]-2- hydroxy-

, trisodium salt.6360-54-9........................ C.I. Direct Brown 30120............... Benzoic acid, 5-[[4[min]-[[2,6-

154. diamino-3-methyl-5-[(4-

sulfophenyl)azo]phenyl]

azo][1,1[min]-biphenyl]-4-

yl]azo]-2- hydroxy-3-methyl-,

disodium salt.8014-91-3........................ C.I. Direct Brown 74 36300............... Benzoic acid, 3,3[min]-[(3,7-

disulfo-1,5-naphthalenediyl)bis

[azo(6-hydroxy-3,1-

phenylene)azo[6(or7)-sulfo-4,1-

naphthalenediyl]azo[1,1[min]-

biphenyl]-4,4[min]-

diylazo]]bis[6-hydroxy-,

hexasodium salt.16071-86-6....................... C.I. Direct Brown 95 30145............... Cuprate(2-), [5-[[4[min]-[[2,6-

dihydroxy-3-[(2-hydroxy-5-

sulfophenyl)azo]phenyl]

azo][1,1[min]- biphenyl]-4-

yl]azo]-2-hydroxybenzoato(4-)]-,

disodium salt.----------------------------------------------------------------------------------------------------------------

(2) The significant new uses are:

(i) For each of the chemical substances listed in Table 2 of this section, any use other than use as a reagent to test for hydrogen peroxide in milk; a reagent to test for hydrogen sulfate, hydrogen cyanide, and nicotine; a stain in microscopy; a reagent for detecting blood; an analytical standard; and, additionally for Colour Index (C.I.) Direct Red 28 (Congo Red) (CAS No. 573-58-0), an indicator dye.

(ii) For the chemical substances listed in Table 1 of this section: Any use.

(b) Specific requirements. The provisions of subpart A of this part apply to this section except as modified by this paragraph (b).

(1) Revocation of certain notification exemptions. The provisions of Sec. 721.45(f) do not apply to this section. A person who imports or processes a chemical substance identified in paragraph (a)(1) of this section as part of an article for a significant new use described in paragraph (a)(2) of this section is not exempt from submitting a significant new use notice.

(2) [Reserved] [79 FR 77909, Dec. 29, 2014]